Quinolactacin A – Inhibits TNF-? production in LPS-stimulate...

For Research Use Only. Not for human or veterinary use.

Quinolactacin A Product ID: BLK-1140
Structure
Molecular Formula	C16H18N2O2
Molecular Weight	270.33
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium citrinum.
Summary	Quinolactacin A Fungal 4-quinolone metabolite that inhibits TNF production.
Details	Quinolactacin A is a secondary metabolite produced by Penicillium species and structurally classified as an N methyl 4 quinolone conjugated with a gamma lactam moiety. It was originally identified as a potent inhibitor of tumor necrosis factor TNF production in lipopolysaccharide stimulated murine macrophages. Isotope labeling studies clarified its biosynthetic origin from acetate anthranilate isoleucine and methionine precursors. Subsequent heterologous expression and enzymatic reconstitution revealed a concise nonribosomal peptide synthetase NRPS dependent pathway responsible for quinolactacin assembly.
Mechanism	Inhibits TNF-? production in LPS-stimulated immune cells.
Primary Target	Tumor necrosis factor alpha (TNF-?)
Pathway	LPS-induced TNF signaling pathway
Chemical Class	4-Quinolone ?-lactam
Discovery Year	2000
Keywords	tnf production inhibitor4-quinolone natural productlipopolysaccharide response inhibitorpenicillium metabolitenrps-derived metaboliteanti-inflammatory research tool
References	Kobayashi et al., J Antibiot, 2000 DOI: 10.7164/antibiotics.53.1247 Kobayashi et al., J Antibiot, 2006 DOI: 10.1038/ja.2006.59 Ye et al., Org Lett, 2020 DOI: 10.1021/acs.orglett.0c02426
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