Citrinin – Induces oxidative stress via ROS generatio...

For Research Use Only. Not for human or veterinary use.

Citrinin Product ID: BLK-0390
Structure
CAS	518-75-2
Molecular Formula	C13H14O5
Molecular Weight	250.25
UN (Transport)	UN2811
Price	1mg: USD 27.00 / 5mg: USD 98.00 / 25mg: USD 350.00
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium citrinum.
Summary	Citrinin Nephrotoxic fungal polyketide mycotoxin widely used to model oxidative stress.
Details	Citrinin is a polyketide mycotoxin produced by several Penicillium and Aspergillus species and is frequently detected as a food contaminant. It is associated with nephrotoxicity and has been implicated in Balkan endemic nephropathy. Mechanistic studies in yeast demonstrate that citrinin induces strong oxidative stress, activates Yap1/Skn7-dependent antioxidant pathways, and stimulates multidrug resistance transport systems. Citrinin is widely used as a research tool to study oxidative stress responses, mycotoxin toxicity, and cellular detoxification mechanisms.
Mechanism	Induces oxidative stress via ROS generation and mitochondrial dysfunction, leading to nephrotoxicity.
Primary Target	Cellular antioxidant response regulators
Pathway	Oxidative stress response; Cellular detoxification signaling
Chemical Class	Polyketide mycotoxin
Discovery Year	1931
Keywords	nephrotoxic mycotoxinoxidative stress inducerreactive oxygen species generatorfood contaminant toxinfungal polyketidepenicillium metaboliteaspergillus metabolitetoxicology research tool
References	Hetherington & Raistrick, Biochem J, 1931 DOI: 10.1042/bj0250470 Oxford & Raistrick, Nature, 1947 DOI: 10.1038/160331b0 Iwahashi et al., Nutrients, 2014 DOI: 10.3390/nu6052077 Iwahashi et al., Toxins, 2016 DOI: 10.3390/toxins8100273
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF
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