Rasfonin – Suppresses KRAS-driven signaling and induc...

For Research Use Only. Not for human or veterinary use.

Rasfonin Product ID: BLK-1330
Structure
CAS	303156-68-5
Molecular Formula	C25H38O6
Molecular Weight	434.57
Price	1mg: USD 290.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Trichurus sp.
Summary	Rasfonin Fungal 2-pyrone metabolite with immunomodulatory and anticancer activity.
Details	Rasfonin is a fungal secondary metabolite first identified as an immunosuppressive compound and later recognized as an inhibitor of KRAS dependent cancer cell growth. It suppresses Ras MAPK signaling by reducing Sos1 expression, leading to decreased Ras activation and downstream Raf MEK ERK phosphorylation. Rasfonin induces reactive oxygen species generation, activates JNK signaling, and promotes autophagy and caspase dependent apoptosis. In vivo studies demonstrated inhibition of KRAS mutated tumor growth.
Mechanism	Suppresses KRAS-driven signaling and induces ROS-mediated autophagy and apoptosis.
Primary Target	KRAS
Pathway	Ras/MAPK signaling pathway
Chemical Class	2-Pyrone polyketide
Discovery Year	2005
Keywords	rasmapk pathway modulator2-pyrone derivativeautophagy inducerros activatorfungal polyketideapoptosis research compound
References	Kimura et al., Chem Pharm Bull, 2005 DOI: 10.1248/cpb.53.923 Liu et al., Cell Death Dis, 2014 DOI: 10.1038/cddis.2014.213 Zhang et al., Autophagy, 2016 DOI: 10.1080/21501203.2016.1170073 Wang et al., J South Med Univ, 2019 DOI: 10.19723/j.issn.1671-167X.2019.02.006 Hoffmeister et al., Fungal Biol Biotechnol, 2023 DOI: 10.1186/s40694-023-00158-x
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