10,11-Dehydrocurvularin – Inhibits NLRP3 inflammasome activation by ...

For Research Use Only. Not for human or veterinary use.

10,11-Dehydrocurvularin Product ID: BLK-1230
Structure
CAS	1095588-70-7
Molecular Formula	C16H18O5
Molecular Weight	290.31
Price	1mg: USD 90.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Aspergillus sp.
Summary	10,11-Dehydrocurvularin Benzenediol lactone macrolide that suppresses NLRP3 inflammasome activation.
Details	10,11-Dehydrocurvularin is a 12-membered benzenediol lactone (BDL) macrolide produced by diverse fungal species as a secondary metabolite. It selectively inhibits NLRP3 inflammasome activation by interfering with the NEK7鋒LRP3 interaction, resulting in reduced caspase-1 activation and diminished IL-1? secretion. The C=C double bond at positions 10,11 is essential for its inflammasome inhibitory activity. Beyond anti-inflammatory effects, 10,11-dehydrocurvularin exhibits cytotoxic and antitumor activities, making it a valuable scaffold for inflammasome biology and inflammation-related drug discovery.
Mechanism	Inhibits NLRP3 inflammasome activation by disrupting NEK7鋒LRP3 interaction, reducing IL-1? maturation.
Primary Target	NLRP3 inflammasome complex
Pathway	NLRP3 inflammasome signaling pathway
Chemical Class	Benzenediol lactone (RAL-type)
Discovery Year	1968
Keywords	nlrp3 inflammasome inhibitornek7-nlrp3 interaction disruptoril-1? suppressorcaspase-1 inhibitorbenzenediol lactone macrolidefungal polyketideinflammasome pathway research tool
References	Barnes et al., J Toxicol Environ Health, 1976 DOI: 10.1080/03601237609372044 Zhang et al., Acta Pharm Sin B, 2023 DOI: 10.1016/S1875-5364(23)60418-2 Li et al., Curr Med Chem, 2021 DOI: 10.2174/1389557521666210428132256 Liu et al., J Antibiot, 2015 DOI: 10.1038/ja.2015.85
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