Aspergillin PZ – Induces fungal morphological disruption; m...

For Research Use Only. Not for human or veterinary use.

Aspergillin PZ Product ID: BLK-1220
Structure
CAS	483305-08-4
Molecular Formula	C24H35NO4
Molecular Weight	401.55
Price	1mg: USD 110.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Aspergillus sp.
Summary	Aspergillin PZ Isoindole alkaloid from Aspergillus awamori featuring a distinctive oxabicyclic core.
Details	Aspergillin PZ is a fungal isoindole alkaloid isolated from Aspergillus awamori and characterized by a rare oxabicyclic ring system confirmed by X-ray crystallography. It was found to moderately induce morphological deformation of Pyricularia oryzae conidia. The structural complexity of aspergillin PZ has attracted synthetic interest, and its total synthesis was achieved via a 2-oxonia[3,3]sigmatropic rearrangement/aldol cascade mechanism. Although synthetic material showed limited cytotoxic activity, aspergillin PZ remains a notable example of structurally remarkable fungal alkaloids.
Mechanism	Induces fungal morphological disruption; molecular target not defined.
Primary Target	Not identified
Pathway	Secondary metabolite biosynthesis
Chemical Class	Isoindole alkaloid
Discovery Year	2002
Keywords	isoindole alkaloidoxabicyclic scaffoldfungal secondary metaboliteaspergillus awamori metaboliteconidia morphology modulatorheterocyclic alkaloid scaffold
References	Kobayashi M et al., J Antibiot (Tokyo), 2002, 55:693-697 DOI: 10.7164/antibiotics.55.693 Clark JS et al., Tetrahedron, 2011, 67:8927-8936 DOI: 10.1016/j.tet.2011.09.079
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF
← Back to Catalog