Neoxaline – Prenylated indoline alkaloid with weak CNS...

For Research Use Only. Not for human or veterinary use.

Neoxaline Product ID: BLK-0530
Structure
CAS	71812-10-7
Molecular Formula	C23H25N5O4
Molecular Weight	435.48
Price	1mg: USD 90.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Aspergillus japonicus.
Summary	Neoxaline Fungal indoline spiroaminal alkaloid with weak central nervous system activity.
Details	Neoxaline is a prenylated indoline spiroaminal alkaloid isolated from Aspergillus japonicus. Structurally characterized by a tetracyclic indoline spiroaminal framework containing a reverse prenyl group and dehydrohistidine-derived unit, it represents a unique fungal alkaloid scaffold. Although it lacks antimicrobial activity, neoxaline exhibits weak central nervous system stimulant effects, indicating interaction with neuroactive pathways. It has primarily served as a structural and synthetic target, with multiple stereoselective total syntheses establishing its absolute configuration and highlighting its complex spirocyclic architecture.
Mechanism	Prenylated indoline alkaloid with weak CNS stimulatory activity; molecular target not identified.
Primary Target	Not identified
Pathway	Neuroactive signaling pathways
Chemical Class	Prenylated indoline spiroaminal alkaloid
Discovery Year	1979
Keywords	indoline spiroaminal alkaloidprenylated fungal alkaloidcns stimulant natural productaspergillus japonicus metaboliteheterocyclic alkaloid scaffold
References	Uchida et al., J Antibiot, 1979 DOI: 10.7164/antibiotics.32.781 Lanman et al., Org Lett, 2005 DOI: 10.1021/ol050077y Kim et al., J Am Chem Soc, 2013 DOI: 10.1021/ja406657v
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