11-O-Methylpseurotin A – Selective synthetic lethality probe active...

For Research Use Only. Not for human or veterinary use.

11-O-Methylpseurotin A Product ID: BLK-0930
Structure
CAS	956904-34-0
Molecular Formula	C23H27NO8
Molecular Weight	445.47
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Sporothrix sp.
Summary	11-O-Methylpseurotin A PKS-NRPS謀erived pseurotin analogue used as a chemical genetics probe.
Details	11-O-Methylpseurotin A is a PKS-NRPS hybrid secondary metabolite isolated from marine-derived Aspergillus fumigatus. Identified through a synthetic lethality yeast screen, it selectively inhibits a Hof1 deletion strain of Saccharomyces cerevisiae, suggesting interference with cytokinesis or cell cycle regulation. Structurally related to pseurotin A, it belongs to the heterospirocyclic ?-lactam family of pseurotins. Although its direct molecular target remains undefined, its selective activity makes it a valuable chemical genetics tool for probing cell division pathways.
Mechanism	Selective synthetic lethality probe active in Hof1-deficient yeast; molecular target not fully defined.
Primary Target	Not identified
Pathway	Cytokinesis pathway
Chemical Class	PKS鋒RPS hybrid spiro-?-lactam
Discovery Year	2007
Keywords	pks-nrps hybrid metabolitesynthetic lethality probecell cycle inhibitoraspergillus fumigatus metabolitechemical genetics research tool
References	Belofsky et al., J Nat Prod, 2007 DOI: 10.1021/np070307c Brunhofer et al., ACS Chem Neurosci, 2018 DOI: 10.1021/acschemneuro.8b00060 Rateb et al., Front Microbiol, 2017 DOI: 10.3389/fmicb.2017.01284
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