Thailandolide B – Merodrimane meroterpenoid evaluated for an...

For Research Use Only. Not for human or veterinary use.

Thailandolide B Product ID: BLK-1120
Structure
CAS	944726-62-9
Molecular Formula	C27H32O8
Molecular Weight	484.55
Price	1mg: USD 170.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium sp.
Summary	Thailandolide B Merodrimane-type meroterpenoid evaluated for antimicrobial activity.
Details	Thailandolide B is a merodrimane-type meroterpenoid isolated from Talaromyces thailandiasis and structurally related species such as Talaromyces amestolkiae. Its structure was elucidated by spectroscopic analyses and confirmed by X-ray crystallography in related analogues. Additional configurational assignments were supported by TDDFT ECD and ORD calculations in subsequent studies of ent-thailandolide B. Although thailandolide B and related metabolites were evaluated for antimicrobial activity against bacteria and fungi, no specific molecular target or defined mechanism of action has been reported. Thus, thailandolide B is currently characterized primarily as a structurally defined fungal meroterpenoid with screened antimicrobial properties.
Mechanism	Merodrimane meroterpenoid evaluated for antimicrobial activity; precise molecular target not established.
Primary Target	Not identified
Pathway	Meroterpenoid biosynthesis pathway
Chemical Class	Merodrimane meroterpenoid
Discovery Year	2007
Keywords	merodrimane meroterpenoidantimicrobial screening compoundtalaromyces metabolitefreshwater fungus metabolitepolyketide-terpenoid hybridsecondary metabolite research scaffold
References	Schneider et al., J Nat Prod, 2007 (isolation and structural elucidation of thailandolides A and B) DOI: 10.1021/np0680578 Harned et al., Tetrahedron Lett, 2021 (ent-thailandolide B; structural analysis; antimicrobial evaluation) DOI: 10.1016/j.tetlet.2021.153067
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