Amidepsine D – Structurally related depside; molecular ta...

For Research Use Only. Not for human or veterinary use.

Amidepsine D Product ID: BLK-0314
Structure
CAS	79786-34-8
Molecular Formula	C26H24O10
Molecular Weight	496.47
Price	1mg: USD 210.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	2,4-di-O-methylgryphoric acid
Purity	>95%
Source Organism	Humicola sp.
Summary	Amidepsine D Fungal depside structurally related to DGAT-inhibiting amidepsines and studied as a lipid biosynthesis scaffold.
Details	Amidepsine D is a fungal secondary metabolite isolated from the DGAT inhibitor-producing strain Humicola sp. FO-2942. Structural analysis identified amidepsine D as 2,4-di-O-methylgryphoric acid, a depside-type aromatic compound. Unlike amidepsines A砲, which possess N-alanine or N-valine amide moieties and exhibit DGAT inhibitory activity, amidepsine D corresponds to a methylated gryphoric acid derivative and represents a structurally related metabolite from the same biosynthetic context.
Mechanism	Structurally related depside; molecular target not fully defined.
Primary Target	Not identified
Pathway	Secondary metabolite biosynthesis
Chemical Class	Depside
Discovery Year	1995
Keywords	depside natural productgryphoric acid derivativefungal metaboliteamidepsine-related compoundsecondary metabolite scaffold
References	Omura S et al., J Antibiot (Tokyo), 1995, 48:937-941 DOI: 10.7164/antibiotics.48.937 Omura S et al., J Antibiot (Tokyo), 1995, 48:942-945 DOI: 10.7164/antibiotics.48.942
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