Funalenone – Inhibits HIV-1 integrase and matrix metall...

For Research Use Only. Not for human or veterinary use.

Funalenone Product ID: BLK-0690
Structure
CAS	259728-61-5
Molecular Formula	C15H12O6
Molecular Weight	288.25
Price	1mg: USD 190.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Aspergillus sp.
Summary	Funalenone Fungal phenalenone that inhibits HIV-1 integrase and type I collagenase (MMP-1).
Details	Funalenone is a phenalenone secondary metabolite originally isolated from Aspergillus niger. It inhibits type I collagenase (MMP-1) and displays selective inhibition of HIV-1 integrase with micromolar potency, leading to suppression of viral replication in vitro. The compound shows greater activity against MMP-1 than against type IV collagenases and demonstrates favorable selectivity in antiviral assays. As a dual integrase and metalloproteinase inhibitor, funalenone represents a valuable phenalenone scaffold for antiviral and matrix biology research.
Mechanism	Inhibits HIV-1 integrase and matrix metalloproteinase-1 (MMP-1), blocking viral integration and extracellular matrix degradation.
Primary Target	HIV-1 integrase; Matrix metalloproteinase-1 (MMP-1)
Pathway	Viral integration pathway; Extracellular matrix remodeling
Chemical Class	Phenalenone polyketide
Discovery Year	1999
Keywords	hiv-1 integrase inhibitormmp-1 inhibitorcollagenase inhibitorphenalenone natural productaspergillus metaboliteantiviral research scaffold
References	Umezawa et al., J Antibiot, 1999 DOI: 10.7164/antibiotics.52.1095 Oh et al., J Antibiot, 2005 DOI: 10.1038/ja.2005.8
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