Aspochalasin I – Inhibits actin polymerization, disrupting ...

For Research Use Only. Not for human or veterinary use.

Aspochalasin I Product ID: BLK-1270
Structure
CAS	670225-69-1
Molecular Formula	C24H35NO5
Molecular Weight	417.55
Price	1mg: USD 180.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Aspergillus sp.
Summary	Aspochalasin I Cytochalasan that disrupts actin dynamics and suppresses melanin production.
Details	Aspochalasin I is a cytochalasan-type secondary metabolite isolated from Aspergillus species. Its structure was established by spectroscopic analysis including NMR and mass spectrometry. Biologically, aspochalasin I inhibits melanogenesis in Mel-Ab melanocyte cells with an IC50 value of 22.4 ｵM without detectable cytotoxicity. Although cytochalasans are generally associated with actin cytoskeleton modulation, aspochalasin I has primarily been characterized for its melanin synthesis inhibitory activity.
Mechanism	Inhibits actin polymerization, disrupting cytoskeletal dynamics.
Primary Target	Not identified (melanogenesis pathway modulation)
Pathway	Melanin biosynthesis
Chemical Class	Cytochalasan (PKS鋒RPS hybrid)
Discovery Year	2008
Keywords	cytochalasanactin polymerization modulatormelanogenesis inhibitormelanin suppression agentfungal secondary metaboliteaspergillus metabolitecytoskeleton research tool
References	Kim YH et al., J Microbiol Biotechnol, 2008, 18:389-393 DOI: 10.4014/jmb.0806.389 Wang G et al., J Nat Prod, 2003, 66:1193-1196 DOI: 10.1021/np030353m
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