Chaetoglobosine A – Cytochalasan that binds actin filaments an...

For Research Use Only. Not for human or veterinary use.

Chaetoglobosine A Product ID: BLK-1180
Structure
CAS	50335-03-0
Molecular Formula	C32H36N2O5
Molecular Weight	528.65
Price	1mg: USD 70.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Chaetomium sp.
Summary	Chaetoglobosine A Cytochalasan that disrupts actin dynamics and exhibits antifungal and cytotoxic activity.
Details	Chaetoglobosin A is a cytochalasan-type secondary metabolite produced by Chaetomium globosum via a PKS-NRPS hybrid biosynthetic pathway. Structurally related to cytochalasins, it disrupts actin polymerization and exhibits potent antifungal, antiparasitic, and antitumor activities. Genetic studies have shown that pathway-specific regulators and transporters strongly influence chaetoglobosin A biosynthesis and secretion. It contributes significantly to the biocontrol activity of Chaetomium strains against plant pathogens and has been investigated for agricultural and biomedical applications. Toxicological studies demonstrate cytotoxic effects consistent with actin-disrupting compounds.
Mechanism	Cytochalasan that binds actin filaments and inhibits polymerization, disrupting cytoskeletal organization.
Primary Target	Actin cytoskeleton (actin polymerization machinery)
Pathway	Actin cytoskeleton regulation
Chemical Class	Cytochalasan (PKS鋒RPS hybrid)
Discovery Year	1973
Keywords	actin polymerization inhibitorcytochalasanpks-nrps hybrid metaboliteantifungal compoundantitumor agentchaetomium metabolitefungal mycotoxincytoskeleton research tool
References	Yang et al., Fungal Biol, 2021 DOI: 10.1016/j.funbio.2020.10.010 Wang et al., Phytopathology, 2023 DOI: 10.1094/PHYTO-01-23-0036-R Zhang et al., Microb Biotechnol, 2023 DOI: 10.1111/1751-7915.14111
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