PF1140 – Chelates Fe3+ via its N-hydroxypyridone mo...

For Research Use Only. Not for human or veterinary use.

PF1140 Product ID: BLK-1610
Structure
CAS	173560-58-2
Molecular Formula	C16H23NO3
Molecular Weight	277.37
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium raphiae
Summary	PF1140 Fungal N-hydroxypyridone natural product that chelates iron and exhibits antifungal activity.
Details	PF1140 is an N-hydroxypyridone secondary metabolite isolated from various Penicillium species and structurally characterized by X-ray crystallography. Its N-hydroxypyridone moiety enables strong Fe3+ chelation, conferring siderophore-like properties under physiological conditions. PF1140 exhibits antifungal activity, notably against Hymenoscyphus fraxineus, and has demonstrated antibacterial effects against Mycoplasma genitalium, potentially via iron-mediated oxidative stress. These properties highlight its role in fungal chemical ecology and iron-dependent cytotoxicity mechanisms. PF1140 represents a valuable scaffold for studying iron-binding natural products and redox-driven antimicrobial activity.
Mechanism	Chelates Fe3+ via its N-hydroxypyridone moiety, disrupting iron-dependent oxidative processes.
Primary Target	Ferric iron (Fe3+)
Pathway	Iron homeostasis; Oxidative stress response
Chemical Class	N-Hydroxypyridone alkaloid
Discovery Year	2005
Keywords	iron chelatorn-hydroxypyridone metaboliteantifungal compoundpenicillium metabolitesiderophore-like natural productiron biology research tool
References	Harrison et al., J Antibiot, 2005 DOI: 10.1038/ja.2005.56 Bremner et al., J Nat Prod, 2008 DOI: 10.1021/np800627f M?ler et al., Appl Environ Microbiol, 2024 DOI: 10.1128/aem.00665-24 Smith et al., J Nat Prod, 2024 DOI: 10.1021/acs.jnatprod.4c00209
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF
← Back to Catalog