Dimerumic acid – Hydroxamate siderophore that chelates Fe3+...

For Research Use Only. Not for human or veterinary use.

Dimerumic acid Product ID: BLK-1630
Structure
CAS	26912-16-3
Molecular Formula	C22H36N4O8
Molecular Weight	484.55
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Pochonia sp.
Summary	Dimerumic acid Hydroxamate siderophore that chelates iron and is used in oxidative stress research.
Details	Dimerumic acid is a fungal hydroxamic acid膨ontaining siderophore identified as a cleavage product of coprogen-type iron chelators and independently produced by several fungi. It functions as an iron-chelating metabolite under iron-deficient conditions and is biosynthesized via NRPS-dependent pathways. Mechanistically, dimerumic acid donates an electron through its hydroxamic acid group to neutralize reactive oxygen species, forming a nitroxide radical and inhibiting lipid peroxidation. It protects hepatocytes from oxidative stress吠nduced cytotoxicity and serves as a chemical probe for studying iron homeostasis and antioxidant defense.
Mechanism	Hydroxamate siderophore that chelates Fe3+ and reduces oxidative stress卜ediated lipid peroxidation.
Primary Target	Ferric iron (Fe3+)
Pathway	Iron acquisition pathway; Oxidative stress response
Chemical Class	Cyclic trihydroxamate siderophore
Discovery Year	1985
Keywords	iron chelatorhydroxamate siderophorelipid peroxidation inhibitorantioxidant compoundnrps-derived metabolitefungal metaboliteoxidative stress research tool
References	Llinas et al., Biochemistry, 1985 DOI: 10.1021/bi00512a011 Akihisa et al., Biochem Pharmacol, 2001 DOI: 10.1016/S0006-2952(01)00923-6 Zhang et al., Front Microbiol, 2021 DOI: 10.3389/fmicb.2021.783609 Honda et al., Cell Biol Toxicol, 2008 DOI: 10.1007/s10565-007-9037-7
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