Pyridoxatin – Iron-chelating hydroxamate metabolite with...

For Research Use Only. Not for human or veterinary use.

Pyridoxatin Product ID: BLK-1080
Structure
CAS	135529-30-5
Molecular Formula	C15H21NO3
Molecular Weight	263.33
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Albophoma yamanashiensis.
Summary	Pyridoxatin Fungal N-hydroxypyridone metabolite with iron-chelating and antifungal activity.
Details	Pyridoxatin is a hydroxamate containing fungal secondary metabolite first identified as an inducer of erythropoietin gene expression in human cells. Structurally classified as an N-hydroxy pyridone, pyridoxatin functions as an iron III chelating agent and exhibits antioxidant properties under iron dependent oxidative stress conditions. Mechanistic studies demonstrated that pyridoxatin inhibits ergosterol biosynthesis in Candida species leading to antifungal activity independent of efflux pump mechanisms. Recent phenotypic screening studies further identified pyridoxatin as a promising lead compound against drug resistant Acinetobacter baumannii.
Mechanism	Iron-chelating hydroxamate metabolite with antifungal activity.
Primary Target	Ferric iron (Fe3+)
Pathway	Ergosterol biosynthesis; Iron chelation
Chemical Class	Hydroxamate alkaloid
Discovery Year	1998
Keywords	n-hydroxypyridone metaboliteiron chelatorergosterol biosynthesis inhibitorantifungal compoundhydroxamate natural productfungal secondary metabolite
References	Kato et al., J Nat Prod, 1998 DOI: 10.1021/np980450t Li et al., Biochim Biophys Acta, 2015 DOI: 10.1016/j.bbagen.2015.05.005 Carvalho et al., Biometals, 2019 DOI: 10.1007/s10534-019-00202-7 Silva et al., Phytochem Lett, 2023 DOI: 10.1016/j.phytol.2023.04.002 Wu et al., Mar Drugs, 2014 DOI: 10.3390/md12031208
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