Nocardamine – Cyclic trihydroxamate siderophore that che...

For Research Use Only. Not for human or veterinary use.

Nocardamine Product ID: BLK-0680
Structure
CAS	26605-16-3
Molecular Formula	C27H48N6O9
Molecular Weight	600.71
Price	1mg: USD 100.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Desferrioxamine E
Purity	>95%
Source Organism	Streptomyces sp.
Summary	Nocardamine Cyclic hydroxamate siderophore that chelates Fe3+ in iron metabolism studies.
Details	Nocardamine, also known as desferrioxamine E, is a cyclic trihydroxamate siderophore produced by Streptomyces species that binds ferric iron (Fe3+) with extremely high affinity. By forming a stable hexadentate Fe3+ complex, it mediates iron uptake in bacteria via specific outer membrane transporters such as FoxA and can also deprive pathogens of iron under limiting conditions. Nocardamine exhibits antimalarial activity through iron chelation卜ediated growth inhibition and has been used as a probe to study siderophore-dependent transport systems. Its strong and selective Fe3+ binding makes it a valuable research tool for dissecting iron acquisition, microbial competition, and iron-dependent metabolic pathways.
Mechanism	Cyclic trihydroxamate siderophore that chelates Fe3+, inhibiting iron-dependent biological processes.
Primary Target	Ferric iron (Fe3+)
Pathway	Iron acquisition pathway; Siderophore transport
Chemical Class	Cyclic trihydroxamate siderophore
Discovery Year	1976
Keywords	siderophoreiron chelatorfe3+ chelation compoundhydroxamate metabolitefoxa transporter ligandantimalarial iron depletion research tool
References	DeBoer et al., J Antibiot, 1976 DOI: 10.7164/antibiotics.29.1182 Lamont et al., ACS Chem Biol, 2020 DOI: 10.1021/acschembio.0c00535 Ong et al., Molecules, 2022 DOI: 10.3390/molecules27072292 Liu et al., npj Biofilms Microbiomes, 2024 DOI: 10.1038/s41429-024-00763-x
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF
← Back to Catalog