Boromycin – Boron-containing polyether ionophore that ...

For Research Use Only. Not for human or veterinary use.

Boromycin Product ID: BLK-1280
Structure
CAS	34524-20-4
Molecular Formula	C45H74BNO15
Molecular Weight	879.9
Price	1mg: USD 300.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Streptomyces sp.
Summary	Boromycin Boron-containing macrolide with potent nanomolar antiparasitic activity.
Details	Boromycin is a boron-containing polyether macrolide antibiotic produced by Streptomyces antibioticus. It exhibits potent nanomolar activity against multiple apicomplexan parasites including Plasmodium falciparum, Toxoplasma gondii and Cryptosporidium parvum, with rapid killing of asexual and sexual blood stages of malaria parasites. Boromycin also shows antiviral activity against HIV-1 and displays ionophore-like effects on membrane function. Its broad antiparasitic profile and rapid onset of action make it a promising candidate for antiparasitic drug development.
Mechanism	Boron-containing polyether ionophore that collapses parasite ion gradients, rapidly disrupting membrane potential and energy metabolism.
Primary Target	Parasite membrane ion homeostasis components
Pathway	Parasite proliferation; Membrane ion homeostasis
Chemical Class	Boron-containing polyether macrolide
Discovery Year	1967
Keywords	boron-containing macrolidepolyether antibioticionophore-like compoundantiparasitic agentantimalarial compoundanti-toxoplasma activityanti-cryptosporidium activitymicrobial natural product
References	Hern疣dez et al., Antimicrob Agents Chemother, 2020 DOI: 10.1128/AAC.01278-20 Breitbach et al., Front Cell Infect Microbiol, 2021 DOI: 10.3389/fcimb.2021.802294 Kohno et al., Biosci Biotechnol Biochem, 1996 DOI: 10.1271/bbb.60.1036
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