Concanamycin B – Potent inhibitor of vacuolar-type H+-ATPas...

For Research Use Only. Not for human or veterinary use.

Concanamycin B Product ID: BLK-1160
Structure
CAS	81552-33-2
Molecular Formula	C45H73NO14
Molecular Weight	852.08
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Streptomyces sp.
Summary	Concanamycin B V-ATPase穆pecific macrolide inhibitor that blocks lysosomal acidification.
Details	Concanamycin B is an 18-membered macrolide antibiotic isolated from Streptomyces diastatochromogenes and belongs to the concanamycin/folimycin family. It specifically inhibits vacuolar-type H+-ATPase (V-ATPase), thereby preventing ATP-dependent acidification of endosomes, lysosomes, and osteoclastic resorption lacunae. Through inhibition of organelle acidification, concanamycin B suppresses antigen presentation via MHC class II and blocks osteoclast-mediated bone resorption. It is widely used as a mechanistic probe to study vesicular trafficking, receptor recycling, lysosomal function, and pH-dependent cellular processes.
Mechanism	Potent inhibitor of vacuolar-type H+-ATPase (V-ATPase), blocking lysosomal acidification.
Primary Target	Vacuolar-type H+-ATPase (V-ATPase)
Pathway	Endosomal僕ysosomal acidification pathway
Chemical Class	18-membered macrolide
Discovery Year	1984
Keywords	v-atpase inhibitormacrolide antibioticproton pump inhibitorendosomal acidification blockerlysosomal ph modulatorosteoclast activity inhibitorfungal-active antibioticcell biology mechanistic probe
References	Kinashi et al., J Antibiot, 1984 DOI: 10.7164/antibiotics.37.1333 Nishimura et al., Biol Pharm Bull, 1996 DOI: 10.1248/bpb.19.297 Kuwana et al., J Antibiot, 1995 DOI: 10.7164/antibiotics.48.488 Uchida et al., Eur J Biochem, 1992 DOI: 10.1111/j.1432-1033.1992.tb17061.x
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF
← Back to Catalog