Brefeldin A – Inhibits ARF-GEFs , blocking ARF activatio...

For Research Use Only. Not for human or veterinary use.

Brefeldin A Product ID: BLK-1680
Structure
CAS	20350-15-6
Molecular Formula	C16H24O4
Molecular Weight	280.37
Price	1mg: - / 5mg: USD 30.00 / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	BFA
Purity	>95%
Source Organism	Lecanicillium fungicola.
Summary	Brefeldin A Macrolide that inhibits Golgi trafficking and is widely used to induce ER stress and study autophagy.
Details	Brefeldin A is a fungal macrolide metabolite produced by several species including Fusarium and Curvularia. It inhibits ADP-ribosylation factor guanine nucleotide exchange factors (ARF-GEFs), resulting in collapse of the Golgi apparatus into the endoplasmic reticulum and disruption of vesicular trafficking. Brefeldin A is extensively used as a research tool to induce ER stress, modulate autophagy, and study membrane trafficking. It also exhibits anticancer activity through induction of apoptosis and autophagic cell death and has been investigated in colorectal cancer and chronic myeloid leukemia models.
Mechanism	Inhibits ARF-GEFs (e.g., GBF1), blocking ARF activation and vesicular trafficking, leading to Golgi disassembly, ER stress, and apoptosis.
Primary Target	ADP-ribosylation factor guanine nucleotide exchange factors (ARF-GEFs; e.g., GBF1)
Pathway	Vesicular trafficking; ER stress response; Autophagy pathway
Chemical Class	Macrolide lactone
Discovery Year	1968
Keywords	arf-gef inhibitorgolgi apparatus disruptorer stress inducerautophagy inducerapoptosis inducermacrolide antibioticvesicular trafficking inhibitorcell biology research tool
References	Zhou et al., FASEB J, 2018 DOI: 10.1096/fj.201801983R Li et al., Toxins, 2024 DOI: 10.3390/toxins16120548 Chen et al., Curr Drug Targets, 2021 DOI: 10.2174/1871520621666210608110435
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF
← Back to Catalog