Aranorosin – Suppresses Bcl-2卜ediated anti-apoptotic si...

For Research Use Only. Not for human or veterinary use.

Aranorosin Product ID: BLK-1050
Structure
CAS	117184-53-9
Molecular Formula	C23H33NO6
Molecular Weight	419.52
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Gymnascella sp.
Summary	Aranorosin Fungal antibiotic that exhibits antifungal activity and modulates Bcl-2睦egulated apoptotic signaling.
Details	Aranorosin is a novel antibiotic isolated from the fermentation broth of Pseudoarachniotus roseus. Structurally, it contains a unique 1-oxaspiro[4,5]decane ring system. Initially characterized for its antifungal activity, aranorosin was later identified as an inhibitor of Bcl-2睦egulated anti-apoptotic functions. It promotes mitochondrial outer membrane permeabilization, induces loss of mitochondrial membrane potential, activates caspase-9, and enhances apoptosis in Bcl-2撲verexpressing cells. These findings position aranorosin as a natural product scaffold of interest for apoptosis-targeted anticancer research.
Mechanism	Suppresses Bcl-2卜ediated anti-apoptotic signaling, promoting mitochondrial cytochrome c release and caspase-9謀ependent apoptosis.
Primary Target	Bcl-2
Pathway	Mitochondrial apoptosis pathway
Chemical Class	Spirocyclic polyketide
Discovery Year	1988
Keywords	bcl-2 pathway inhibitorapoptosis inducermitochondrial apoptotic pathway activatorantifungal antibioticspirocyclic natural productpseudoarachniotus metaboliteapoptosis research tool
References	Umezawa H et al., J Antibiot (Tokyo), 1988, 41:1780-1784 DOI: 10.7164/antibiotics.41.1780 Umezawa H et al., J Antibiot (Tokyo), 1988, 41:1785-1792 DOI: 10.7164/antibiotics.41.1785 Saito Y et al., Biochem Biophys Res Commun, 2009, 379:76-80 DOI: 10.1016/j.bbrc.2008.10.112
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