Beauvericin – Ionophoric cyclic hexadepsipeptide that fo...

For Research Use Only. Not for human or veterinary use.

Beauvericin Product ID: BLK-0370
Structure
CAS	26048-05-5
Molecular Formula	C45H57N3O9
Molecular Weight	783.97
Price	1mg: USD 32.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Beauveria sp
Summary	Beauvericin Cyclic ionophoric mycotoxin with antimicrobial and anticancer activity.
Details	Beauvericin is a cyclic hexadepsipeptide mycotoxin produced by Fusarium and other filamentous fungi. It acts as a cation-selective ionophore, disrupting ion homeostasis and inducing mitochondrial dysfunction, oxidative stress and apoptosis. Beauvericin exhibits antimicrobial, antiviral, antifungal, insecticidal and anticancer activities, while also being recognized as an emerging food and feed contaminant with documented in vitro and in vivo toxicological effects.
Mechanism	Ionophoric cyclic hexadepsipeptide that forms cation-selective complexes, disrupting membrane ion homeostasis and inducing mitochondrial dysfunction and apoptosis.
Primary Target	Cellular membrane ion gradients
Pathway	Ion homeostasis; Mitochondrial apoptosis
Chemical Class	Cyclic hexadepsipeptide (enniatin family)
Discovery Year	1969
Keywords	cyclic hexadepsipeptideionophoremitochondrial dysfunction inducerapoptosis inducerreactive oxygen species generatorfusarium metaboliteenniatin family mycotoxincytotoxic research compound
References	Mancebo et al., Environ Toxicol Pharmacol, 2020 DOI: 10.1016/j.etap.2020.103349 Prosperini et al., Toxins, 2020 DOI: 10.3390/toxins12110686 Tolosa et al., Toxins, 2021 DOI: 10.3390/toxins13010032
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF
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