Globosuxanthone A – Induces tumor cell apoptosis and inhibits ...

For Research Use Only. Not for human or veterinary use.

Globosuxanthone A Product ID: BLK-1360
Structure
CAS	917091-74-8
Molecular Formula	C15H12O7
Molecular Weight	304.26
Price	1mg: USD 180.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Fungi unknown
Summary	Globosuxanthone A Fungal xanthone that induces tumor cell apoptosis and exhibits antifungal activity.
Details	Globosuxanthone A is a dihydroxanthenone-type xanthone polyketide originally isolated from Chaetomium globosum and later identified in other fungal sources. It exhibits strong cytotoxicity against multiple human solid tumor cell lines, causing disruption of the cell cycle with accumulation in G2/M or S phase and induction of classical apoptotic morphology. In antifungal assays, it shows inhibitory activity against phytopathogens including Fusarium graminearum, Fusarium solani, and Botrytis cinerea, as well as Candida albicans. Its structure and absolute configuration were confirmed by NMR and X-ray crystallographic analysis. Globosuxanthone A represents a bioactive fungal xanthone scaffold with dual anticancer and antifungal properties.
Mechanism	Induces tumor cell apoptosis and inhibits fungal growth.
Primary Target	Cell-cycle regulatory machinery
Pathway	Cell cycle arrest; Apoptosis pathway
Chemical Class	Xanthone polyketide
Discovery Year	2006
Keywords	xanthone derivativeapoptosis inducercell cycle arrest compoundantifungal agentchaetomium metabolitefungal polyketideanticancer research tool
References	Zhang et al., Bioorg Med Chem, 2006 DOI: 10.1016/j.bmc.2006.07.048 Takahashi et al., Mar Drugs, 2010 DOI: 10.3390/md10122691 Li et al., Mycopathologia, 2019 DOI: 10.1007/s12223-019-00762-8
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