Streptochlorin

Streptochlorin is an indole alkaloid isolated from marine Streptomyces species and identified as a bioactive lead compound against phytopathogenic fungi. Structure紡ctivity relationship studies and molecular docking analyses demonstrated that streptochlorin and its synthetic analogues bind to leucyl-tRNA synthetase (LeuRS) in a manner comparable to known LeuRS inhibitors, supporting inhibition of aminoacyl-tRNA synthesis as a plausible mechanism underlying antifungal activity. Several derivatives displayed superior growth inhibition against Alternaria leaf spot, Gibberella zeae and Rhizoctonia solani, with EC50 values outperforming commercial fungicides. These findings position streptochlorin as a marine-derived indole scaffold for antifungal development targeting translational machinery.