Cyclopenol – Suppresses NF-?B謀ependent inflammatory sig...

For Research Use Only. Not for human or veterinary use.

Cyclopenol Product ID: BLK-0750
Structure
CAS	20007-85-6
Molecular Formula	C17H14N2O4
Molecular Weight	310.31
Price	1mg: USD 170.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium sp.
Summary	Cyclopenol Benzodiazepine alkaloid that suppresses NF-?B卜ediated inflammatory signaling.
Details	Cyclopenol is a benzodiazepine-type alkaloid produced by Penicillium species, including marine and mangrove-derived strains. It has been shown to inhibit LPS-induced nitric oxide production and suppress IL-6 and iNOS expression through inhibition of upstream NF-?B activation. Structural studies reveal a 2,5-dioxopiperazine-related scaffold typical of cyclopenin膨yclopenol metabolites. Cyclopenol is used as a chemical probe to study inflammatory signaling and fungal benzodiazepine biosynthesis.
Mechanism	Suppresses NF-?B謀ependent inflammatory signaling and reduces cytokine production.
Primary Target	NF-?B signaling components
Pathway	NF-?B signaling pathway; Cytokine regulation
Chemical Class	Benzodiazepine alkaloid
Discovery Year	1976
Keywords	nf-?b inhibitoranti-inflammatory compoundnitric oxide synthase inhibitorbenzodiazepine alkaloid5-dioxopiperazine scaffoldpenicillium metabolitenatural product research tool
References	Anke et al., J Basic Microbiol, 1984 DOI: 10.1002/jobm.3630240908 Zhang et al., Nat Prod Res, 2014 DOI: 10.1080/10286020.2014.911290 Abdel-Lateff et al., Z Naturforsch C, 2021 DOI: 10.1515/znc-2021-0236
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