Andrastin A – Inhibits protein farnesyltransferase , blo...

For Research Use Only. Not for human or veterinary use.

Andrastin A Product ID: BLK-0720
Structure
CAS	174232-42-9
Molecular Formula	C28H38O7
Molecular Weight	486.61
Price	1mg: USD 190.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium sp.
Summary	Andrastin A Fungal meroterpenoid that inhibits protein farnesyltransferase and is used in Ras prenylation research.
Details	Andrastin A is a meroterpenoid secondary metabolite isolated from the cultured broth of Penicillium sp. FO-3929. It was identified as a protein farnesyltransferase (FTase) inhibitor with an IC50 value of 24.9 ｵM. FTase catalyzes the prenylation of Ras and other CAAX-motif-containing proteins, a post-translational modification required for membrane localization and oncogenic signaling. By inhibiting FTase, Andrastin A interferes with Ras-dependent signaling pathways implicated in tumor development, positioning it as a natural product lead compound for anticancer research.
Mechanism	Inhibits protein farnesyltransferase (FTase), blocking Ras prenylation and downstream oncogenic signaling.
Primary Target	Protein farnesyltransferase (FTase)
Pathway	Ras prenylation pathway; CAAX protein processing
Chemical Class	Meroterpenoid (PKS釦erpene hybrid)
Discovery Year	1996
Keywords	protein farnesyltransferase inhibitorras prenylation inhibitoroncogenic ras signaling modulatormeroterpenoid natural productpenicillium metaboliteanticancer research compound
References	Omura S et al., J Antibiot (Tokyo), 1996, 49:414-417 DOI: 10.7164/antibiotics.49.414 Fernandez-Bodega MA et al., Front Microbiol, 2017, 8:813 DOI: 10.3389/fmicb.2017.00813 Bridge PD et al., Mycol Res, 2005, 109:1117-1124 DOI: 10.1017/S0953756205003734
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