Cyclopenin – Inhibits NF-?B activation and reported to ...

For Research Use Only. Not for human or veterinary use.

Cyclopenin Product ID: BLK-0770
Structure
CAS	19553-26-5
Molecular Formula	C17H14N2O3
Molecular Weight	294.31
Price	1mg: USD 170.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium sp.
Summary	Cyclopenin Benzodiazepine alkaloid that inhibits NF-?B signaling and SARS-CoV-2 Mpro.
Details	Cyclopenin is a benzodiazepine alkaloid produced by Penicillium and Aspergillus species and belongs to the cyclopenin膨yclopenol metabolite family. Recent studies demonstrate that cyclopenin inhibits SARS-CoV-2 main protease (Mpro) in vitro at submicromolar concentrations and suppresses LPS-induced NF-?B activation, reducing nitric oxide and pro-inflammatory cytokine production. In cellular models, it downregulates iNOS, IL-1?, and IL-6 expression and ameliorates inflammation-associated phenotypes. Cyclopenin thus functions as a dual anti-inflammatory and antiviral scaffold with value in chemical biology and drug discovery research.
Mechanism	Inhibits NF-?B activation and reported to suppress SARS-CoV-2 main protease (Mpro) activity.
Primary Target	SARS-CoV-2 main protease (Mpro); NF-?B signaling components
Pathway	Viral polyprotein processing; NF-?B signaling pathway
Chemical Class	Benzodiazepine alkaloid
Discovery Year	1976
Keywords	sars-cov-2 mpro inhibitornf-?b pathway inhibitoranti-inflammatory compoundnitric oxide production suppressorbenzodiazepine alkaloidpenicillium metaboliteantiviral research scaffold
References	Anke et al., J Basic Microbiol, 1984 DOI: 10.1002/jobm.3630240908 Elissawy et al., Biomolecules, 2021 DOI: 10.3390/biom11091366 Chen et al., Pharmacol Res, 2020 DOI: 10.1038/s41429-020-0302-9
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