Fulvic Acid – Inhibits tau aggregation and modulates MAP...

For Research Use Only. Not for human or veterinary use.

Fulvic Acid Product ID: BLK-0430
Structure
CAS	479-66-3
Molecular Formula	C14H12O8
Molecular Weight	308.25
Price	1mg: USD 80.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium sp.
Summary	Fulvic Acid Fungal-derived phenolic humic substance that inhibits tau aggregation and modulates inflammatory signaling.
Details	Fulvic acid is a low-molecular-weight phenolic humic substance originally identified as a fungal metabolic product and later recognized as a bioactive natural compound. It inhibits tau protein fibril formation and promotes disassembly of preformed paired helical filaments associated with Alzheimer's disease. Additionally, fulvic acid downregulates inflammatory chemokines CCL17 and CCL22 by inhibiting p38 MAPK and JNK phosphorylation, attenuating Th2-driven inflammation in atopic dermatitis models. These combined neuroprotective and anti-inflammatory effects position fulvic acid as a multifunctional natural product scaffold for chronic inflammatory and neurodegenerative disease research.
Mechanism	Inhibits tau aggregation and modulates MAPK signaling pathways.
Primary Target	Tau protein; p38 MAPK; JNK
Pathway	Tau aggregation pathway; MAPK signaling pathway
Chemical Class	Humic phenolic compound
Discovery Year	1935
Keywords	tau aggregation inhibitorp38 mapk pathway modulatorjnk pathway modulatoranti-inflammatory compoundhumic-derived phenolic substanceneuroprotective research scaffold
References	Raistrick et al., Biochem J, 1935 DOI: 10.1042/bj0291102 Cornejo et al., J Alzheimers Dis, 2011 DOI: 10.3233/JAD-2011-110623 Wang et al., Molecules, 2023 DOI: 10.3390/molecules28083507 Vucskits et al., J Diabetes Res, 2018 DOI: 10.1155/2018/5391014
Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF
← Back to Catalog