Herquline A – Inhibits influenza A virus replication; mo...

For Research Use Only. Not for human or veterinary use.

Herquline A Product ID: BLK-1290
Structure
CAS	71812-08-3
Molecular Formula	C19H26N2O2
Molecular Weight	314.43
Price	1mg: USD 300.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium herquei
Summary	Herquline A Fungal piperazine alkaloid with reported anti-influenza activity.
Details	Herquline A is a pentacyclic piperazine alkaloid produced by Penicillium herquei. Originally identified as a weak inhibitor of ADP-induced platelet aggregation, it was later shown to inhibit replication of influenza A virus (A/PR/8/34 strain) in a dose-dependent manner without significant cytotoxicity. Mechanistic studies indicate that herquline A does not inhibit viral neuraminidase, suggesting a distinct antiviral target within the viral replication cycle. Herquline A represents one of the earliest characterized fungal piperazine alkaloids and serves as a structural prototype within this alkaloid class.
Mechanism	Inhibits influenza A virus replication; molecular target not fully characterized.
Primary Target	Influenza A virus replication machinery
Pathway	Viral replication pathway
Chemical Class	Piperazine alkaloid
Discovery Year	1979
Keywords	anti-influenza compoundviral replication inhibitorpiperazine alkaloidpenicillium metaboliteplatelet aggregation inhibitorantiviral research scaffold
References	Omura et al., J Antibiot, 1979 DOI: 10.7164/antibiotics.32.786 Ueda et al., J Antibiot, 2016 DOI: 10.1080/09168451.2016.1162084 Wu et al., Nat Prod Rep, 2022 DOI: 10.1039/d2np00070a
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