(-)-Flavomannin A – Induces G0/G1 cell-cycle arrest and exhibi...

For Research Use Only. Not for human or veterinary use.

(-)-Flavomannin A Product ID: BLK-1500
Structure
CAS	19953-89-0
Molecular Formula	C30H26O10
Molecular Weight	546.54
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Talaromyces sp.
Summary	(-)-Flavomannin A Fungal anthranoid pigment with antiproliferative activity and relevance as an antiplasmodial-related scaffold.
Details	Flavomannin A is a preanthraquinone anthranoid pigment isolated from Cortinarius and related fungal species. Structurally related flavomannins have demonstrated moderate antiplasmodial activity against Plasmodium falciparum and antiproliferative effects in human cancer cell lines. In colorectal Caco-2 cells, flavomannin derivatives induce G0/G1 cell-cycle arrest accompanied by upregulation of p27 without triggering apoptosis. As an anthranoid scaffold linked to both cytostatic and antimalarial activities, flavomannin A serves as a valuable natural product framework for structure紡ctivity relationship studies.
Mechanism	Induces G0/G1 cell-cycle arrest and exhibits antiproliferative activity.
Primary Target	Cell-cycle regulatory proteins
Pathway	Cell cycle regulation; Antiplasmodial pathway
Chemical Class	Anthranoid
Discovery Year	1999
Keywords	anthranoid pigmentantiproliferative compoundg0g1 cell cycle arrest inducerantiplasmodial scaffoldfungal secondary metabolitenatural product research tool
References	Bringmann et al., Parasitol Res, 1999 DOI: 10.1007/s004360050598 Sousa et al., Toxicology, 2009 DOI: 10.1016/j.tox.2009.08.009 Geroldinger et al., Mycol Prog, 2021 DOI: 10.1007/s43630-021-00159-y
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