Elasnin

Elasnin is a polyketide-derived metabolite isolated from Streptomyces noboritoensis and originally identified as a selective inhibitor of human granulocyte elastase. It inhibits human elastase at low micromolar concentrations while showing minimal activity against related serine proteases. More recently, elasnin has been shown to eradicate methicillin-resistant Staphylococcus aureus (MRSA) biofilms, including daptomycin-resistant strains, by disrupting biofilm matrix integrity and repressing cell division, cell wall synthesis, and virulence-associated pathways. Multi-omics analyses indicate interference with key regulatory systems and biofilm maintenance mechanisms, highlighting its potential as a biofilm-targeting anti-virulence agent.