Fuscin – Antagonizes CCR5 receptor and suppresses b...

For Research Use Only. Not for human or veterinary use.

Fuscin Product ID: BLK-0760
Structure
CAS	83-85-2
Molecular Formula	C15H16O5
Molecular Weight	276.29
Price	1mg: USD 150.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Oidiodendron sp.
Summary	Fuscin Fungal polyketide that antagonizes CCR5 and inhibits MRSA growth and biofilm formation.
Details	Fuscin is a polyketide metabolite isolated from Oidiodendron griseum. It competes with macrophage inflammatory protein-1? for binding to the human CCR5 receptor, a key co-receptor involved in HIV-1 entry, thereby functioning as a CCR5 antagonist. Fuscin and related derivatives also display antibacterial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA), with docking studies suggesting interaction with biofilm regulatory proteins such as SarA and AgrA. These properties position fuscin as a dual-function research tool for studying viral entry mechanisms and bacterial virulence regulation.
Mechanism	Antagonizes CCR5 receptor and suppresses bacterial biofilm formation.
Primary Target	CCR5; SarA; AgrA
Pathway	HIV entry pathway; Biofilm regulation
Chemical Class	Polyketide
Discovery Year	2003
Keywords	ccr5 antagonisthiv entry inhibitorantibiofilm agentgram-positive bacteria inhibitorpolyketide metabolitefungal secondary metaboliteinfection research tool
References	Tsunakawa et al., J Nat Prod, 2003 DOI: 10.1021/np030146m Gonz疝ez et al., J Enzyme Inhib Med Chem, 2023 DOI: 10.1080/08927014.2023.2276926 Debitus et al., Mar Drugs, 2017 DOI: 10.3390/md15040111
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