OM173-alphaA – Benzoisochromanequinone antibiotic interfe...

For Research Use Only. Not for human or veterinary use.

OM173-alphaA Product ID: BLK-1190
Structure
CAS	58286-56-9
Molecular Formula	C17H16O6
Molecular Weight	316.31
Price	1mg: USD 170.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Streptomyces rosa subsp. Notoensis
Summary	OM173-alphaA Nanaomycin-type polyketide antibiotic active against mycoplasmas and fungi.
Details	OM173-alphaA is one of several nanaomycin-type antibiotics produced by Streptomyces sp. OM-173. Structurally belonging to the benzoisochromanequinone family of polyketide-derived antibiotics, it shares biosynthetic homology with actinorhodin- and kalafungin-type compounds. OM173-alphaA exhibits activity against mycoplasmas and moderate antifungal effects, consistent with quinone-containing redox-active antibiotics. Biosynthetic gene cluster analysis indicates PKS-derived assembly closely related to nanaomycin and kalafungin pathways. The compound represents a useful scaffold for studying polyketide quinone antibiotic biosynthesis and redox-mediated antimicrobial mechanisms.
Mechanism	Benzoisochromanequinone antibiotic interfering with quinone-dependent redox processes.
Primary Target	Redox-active quinone systems
Pathway	Polyketide quinone biosynthesis; Redox-mediated antimicrobial pathway
Chemical Class	Benzoisochromanequinone polyketide
Discovery Year	1983
Keywords	benzoisochromanequinone antibioticpolyketide antibioticstreptomyces metabolitemycoplasma inhibitorantifungal natural productredox-active quinone
References	?mura et al., J Antibiot, 1983 DOI: 10.7164/antibiotics.36.1268 Kato et al., J Antibiot, 1991 DOI: 10.7164/antibiotics.44.995
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