Chartreusin – Binds GC-rich B-DNA and interferes with RN...

For Research Use Only. Not for human or veterinary use.

Chartreusin Product ID: BLK-1030
Structure
CAS	6377-18-0
Molecular Formula	C32H32O14
Molecular Weight	640.6
Price	1mg: USD 50.00 / 5mg: USD 120.00 / 25mg: -
Storage	-20°C
Solubility	1mg/ml Acetone
Purity	>95%
Source Organism	Streptomyces sp.
Summary	Chartreusin Streptomyces-derived chromoglycoside antibiotic that binds GC-rich DNA and is used in antitumor research.
Details	Chartreusin is an aromatic chromoglycoside polyketide antibiotic originally isolated from Streptomyces chartreusis. It selectively binds GC-rich regions of B-DNA, inhibits RNA synthesis, and induces oxidative single-strand DNA scission. These DNA-directed effects result in antiproliferative activity and have driven development of semi-synthetic derivatives with improved pharmacokinetics. Chartreusin remains a valuable mechanistic probe for studying transcription inhibition and DNA-damage卜ediated cytotoxicity.
Mechanism	Binds GC-rich B-DNA and interferes with RNA synthesis and topoisomerase II紡ssociated DNA processing.
Primary Target	GC-rich B-DNA
Pathway	DNA transcription; Topoisomerase II-associated DNA damage
Chemical Class	Chromoglycoside polyketide (type II PKS)
Discovery Year	1953
Keywords	gc-rich dna-binding antibioticchromoglycoside polyketidetopoisomerase ii inhibitortranscription inhibitorstreptomyces metaboliteantitumor research tooldna-interaction probe
References	Leach et al., J Am Chem Soc, 1953 DOI: 10.1021/ja01112a040 Portugal et al., Curr Med Chem Anti-Cancer Agents, 2003 DOI: 10.2174/1568011033482215 Zhu et al., Ann Transl Med, 2020 DOI: 10.21037/atm.2020.03.227 Xu et al., Angew Chem Int Ed, 2022 DOI: 10.1002/anie.202112047
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