epi-Aszonalenin A – Suppresses LOX-1卜ediated inflammatory sign...

For Research Use Only. Not for human or veterinary use.

epi-Aszonalenin A Product ID: BLK-1150
Structure
Molecular Formula	C25H25N3O3
Molecular Weight	415.49
Price	1mg: USD 120.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Neosartorya fischeri.
Summary	epi-Aszonalenin A Fungal indole alkaloid that inhibits inflammation and angiogenesis.
Details	epi-Aszonalenin A is a prenylated indole alkaloid isolated from Aspergillus species. It suppresses ox-LDL-induced inflammation, angiogenesis and apoptosis in HUVEC cells by downregulating LOX-1 expression and inhibiting NF-?B, PI3K/AKT and MAPK signaling pathways. These properties suggest potential application in atherosclerosis and vascular inflammation research.
Mechanism	Suppresses LOX-1卜ediated inflammatory signaling via inhibition of NF-?B and PI3K/AKT pathways.
Primary Target	LOX-1; NF-?B; VEGFR-2
Pathway	Inflammatory signaling pathway; Angiogenesis pathway
Chemical Class	Prenylated indole alkaloid
Discovery Year	2015
Keywords	lox-1 inhibitornf-?b pathway inhibitoranti-angiogenic compoundpi3kakt pathway modulatormapk signaling modulatorindole alkaloidfungal metaboliteatherosclerosis research tool
References	Zhang et al., Int Immunopharmacol, 2022 DOI: 10.1016/j.intimp.2022.108931 Miyamoto et al., Nat Prod Res, 2015 DOI: 10.1080/14786419.2015.1101107
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