Terpendole C

Terpendole C is an indole-diterpenoid secondary metabolite originally isolated from Albophoma yamanashiensis as part of a series of ACAT inhibitors termed terpendoles. Among the terpendole analogues, terpendole C displayed the most potent inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) with an IC50 value of 2.1 ｵM in vitro, implicating suppression of cholesterol esterification. Subsequent studies of related indole-diterpenes demonstrated tremorgenic activity in mouse models, with terpendole C inducing significant neurotoxic signs. Additional isolation from nematophagous and endophytic fungi confirmed its occurrence across fungal taxa. These findings define terpendole C as a bioactive indole-diterpenoid combining lipid metabolism inhibition with tremorgenic neurotoxicity.