Penicillide – Inhibits acyl-CoA:cholesterol acyltransfer...

For Research Use Only. Not for human or veterinary use.

Penicillide Product ID: BLK-1060
Structure
CAS	55303-92-9
Molecular Formula	C21H24O6
Molecular Weight	372.42
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium sp.
Summary	Penicillide Fungal depsidone metabolite that inhibits ACAT and affects cholesterol esterification.
Details	Penicillide is a depsidone-type secondary metabolite frequently isolated from Penicillium and Talaromyces species and recognized as the founder compound of the penicillide family. It has been studied for its inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT), a key enzyme in cholesterol esterification and foam cell formation. Structure紡ctivity studies of acylated derivatives revealed that small acyl substitutions enhance ACAT inhibitory potency and selectivity in macrophage models. Beyond lipid metabolism research, penicillide derivatives exhibit antifungal and ecological bioactivities, supporting a potential role in fungal defense. Penicillide therefore represents a useful scaffold for studying cholesterol metabolism and fungal secondary metabolite diversification.
Mechanism	Inhibits acyl-CoA:cholesterol acyltransferase (ACAT).
Primary Target	Acyl-CoA:cholesterol acyltransferase (ACAT)
Pathway	Cholesterol esterification pathway
Chemical Class	Depsidone
Discovery Year	1991
Keywords	sterol o-acyltransferase (acat) inhibitorcholesterol esterification inhibitorlipid metabolism modulatordepsidone natural productfungal metabolitemetabolic research tool
References	Tomoda et al., J Antibiot, 1991 DOI: 10.7164/antibiotics.44.152 Takahashi et al., J Antibiot, 2005 DOI: 10.1007/s11418-005-0028-9 Kurobane et al., Molecules, 2024 DOI: 10.3390/molecules29163888
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