Bostrycin – Anthraquinone that induces mitochondrial d...

For Research Use Only. Not for human or veterinary use.

Bostrycin Product ID: BLK-1370
Structure
CAS	21879-81-2
Molecular Formula	C16H16O8
Molecular Weight	336.3
Price	1mg: USD 200.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml DMSO
Purity	>95%
Source Organism	Arthrinium sp.
Summary	Bostrycin Anthraquinone phytotoxin with anticancer and antimycobacterial activity.
Details	Bostrycin is an anthraquinone pigment originally isolated from Alternaria species and identified as a nonspecific phytotoxin capable of inducing necrosis in plant tissues. Beyond its phytotoxic effects, bostrycin exhibits antimicrobial activity and inhibits the growth of Mycobacterium tuberculosis. In cancer models, bostrycin suppresses proliferation and migration of tumor cells by inducing G2/M cell cycle arrest and triggering mitochondrial apoptosis. Proteomic studies suggest that bostrycin may induce oxidative stress and interfere with NAD+ synthesis and TCA cycle processes, highlighting its multifunctional biological activity.
Mechanism	Anthraquinone that induces mitochondrial dysfunction and ROS accumulation, triggering apoptosis and growth inhibition.
Primary Target	Mitochondrial apoptosis regulators
Pathway	Mitochondrial apoptosis; Oxidative stress response; Central carbon metabolism
Chemical Class	Anthraquinone
Discovery Year	1982
Keywords	anthraquinone phytotoxinmitochondrial apoptosis inducerg2m cell cycle arrestoxidative stress induceranticancer research compoundalternaria metabolitefungal secondary metabolite
References	Charudattan et al., Appl Environ Microbiol, 1982 DOI: 10.1128/aem.43.4.846-849.1982 Zhang et al., Transl Cancer Res, 2020 DOI: 10.21037/tcr-19-2076 Liu et al., J Proteomics, 2019 DOI: 10.1016/j.jprot.2019.103576
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