Pyripyropene A – Highly selective sterol O-acyltransferase ...

For Research Use Only. Not for human or veterinary use.

Pyripyropene A Product ID: BLK-0570
Structure
CAS	147444-03-9
Molecular Formula	C31H37NO10
Molecular Weight	583.64
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Aspergillus fumigatus.
Summary	Pyripyropene A Fungal meroterpenoid that selectively inhibits sterol O-acyltransferase 2 (SOAT2/ACAT2).
Details	Pyripyropene A is a secondary metabolite produced by Aspergillus fumigatus and represents one of the most potent and selective inhibitors of sterol O acyltransferase 2 SOAT2 also known as ACAT2. It inhibits cholesterol esterification in microsomal assays with nanomolar potency and shows strong isozyme selectivity over SOAT1. Structure activity relationship studies and synthetic analog development confirmed its role as a lead compound for dyslipidemia and anti atherosclerotic drug discovery. In addition to its lipid metabolism activity, pyripyropene A exhibits strong insecticidal activity against aphids and other sap sucking agricultural pests.
Mechanism	Highly selective sterol O-acyltransferase 2 (SOAT2/ACAT2) inhibitor blocking cholesterol esterification.
Primary Target	Sterol O-acyltransferase 2 (SOAT2; ACAT2)
Pathway	Cholesterol esterification
Chemical Class	Meroterpenoid
Discovery Year	1994
Keywords	sterol o-acyltransferase 2 (soat2) inhibitoracat2 selective inhibitorcholesterol esterification inhibitoraspergillus fumigatus metaboliteanti-atherosclerotic lead compound
References	Omura et al., J Antibiot, 1994 DOI: 10.7164/antibiotics.47.148 Yoshida et al., ChemMedChem, 2017 DOI: 10.1002/cmdc.201700645 Kakeya et al., J Antibiot, 2016 DOI: 10.1038/ja.2016.155 Matsuo et al., J Pestic Sci, 2019 DOI: 10.1584/jpestics.D18-030
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