NG 012 – Enhances NGF-dependent neuronal differenti...

For Research Use Only. Not for human or veterinary use.

NG 012 Product ID: BLK-0650
Structure
CAS	141731-76-2
Molecular Formula	C32H38O15
Molecular Weight	662.65
Price	1mg: USD 90.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
Source Organism	Penicillium sp.
Summary	NG 012 Fungal NGF potentiator that enhances NGF-dependent neurite outgrowth.
Details	NG-012 is a secondary metabolite isolated from Penicillium verruculosum that enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Similar to NG-011, it does not mimic NGF directly but potentiates NGF-dependent signaling pathways, thereby increasing neuronal differentiation responses. Structural studies revealed that NG-012 belongs to a macrocyclic polylactone class of fungal metabolites. It serves as a neurobiology research tool to investigate NGF傍rkA signaling, neuronal differentiation mechanisms, and neurotrophic pathway modulation.
Mechanism	Enhances NGF-dependent neuronal differentiation signaling.
Primary Target	Not identified (NGF signaling enhancement)
Pathway	NGF傍rkA signaling pathway; Neuronal differentiation
Chemical Class	Macrocyclic polylactone
Discovery Year	1992
Keywords	nerve growth factor potentiatorneurite outgrowth stimulatorpc12 differentiation assay toolpenicillium verruculosum metaboliteneurotrophic modulator
References	Kobayashi et al., J Antibiot, 1992 DOI: 10.7164/antibiotics.45.1559 Kobayashi et al., J Antibiot, 1992 DOI: 10.7164/antibiotics.45.1566
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