Name: Penicillide
Brand: Biolinks K.K.
SKU: BLK-1060
Price: 140.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Penicillide (CAS: 55303-92-9) Product ID: BLK-1060 CAS 55303-92-9 Mechanism ACAT inhibitor Primary Target Acyl-CoA:cholesterol acyltransferase (ACAT) Pathway Cholesterol esterification pathway
Structure	View full structure page Chemical structure of Penicillide (CAS 55303-92-9)
CAS	55303-92-9
Molecular Formula	C21H24O6
Molecular Weight	372.42
Price	1mg: USD 140.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Penicillide. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Penicillide.
Source Organism	Penicillium sp.
Summary	Penicillide is a fungal depsidone metabolite that inhibits ACAT and affects cholesterol esterification.
Details	Penicillide is a depsidone-type secondary metabolite frequently isolated from Penicillium and Talaromyces species and recognized as the founder compound of the penicillide family. It has been studied for its inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT), a key enzyme in cholesterol esterification and foam-cell formation. Structure-activity studies of acylated derivatives revealed that small acyl substitutions enhance ACAT inhibitory potency and selectivity in macrophage models. Beyond lipid-metabolism research, penicillide derivatives exhibit antifungal and ecological bioactivities, supporting a potential role in fungal defense. Penicillide therefore represents a useful scaffold for studying cholesterol metabolism and fungal secondary metabolite diversification.
Browse Related	Mechanism ACAT inhibitor Open full index Primary Target Acyl-CoA:cholesterol acyltransferase (ACAT) Open full index Pathway Cholesterol esterification pathway Open full index Chemical Class Depsidone Open full index
Mechanism	ACAT inhibitor
Primary Target	Acyl-CoA:cholesterol acyltransferase (ACAT)
Pathway	Cholesterol esterification pathway
Chemical Class	Depsidone
Discovery Year	1991
Keywords	sterol o-acyltransferase (acat) inhibitor cholesterol esterification inhibitor lipid metabolism modulator depsidone natural product fungal metabolite metabolic research tool
References	Tomoda et al., J Antibiot, 1991 DOI: 10.7164/antibiotics.44.152 Takahashi et al., J Antibiot, 2005 DOI: 10.1007/s11418-005-0028-9 Kurobane et al., Molecules, 2024 DOI: 10.3390/molecules29163888
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Penicillide (CAS: 55303-92-9)