Name: MS-347a
Brand: Biolinks K.K.
SKU: BLK-1710
Price: 360.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

MS-347a (CAS: 144678-18-2) Product ID: BLK-1710 CAS 144678-18-2 Mechanism MLCK inhibitor Primary Target Myosin light chain kinase (MLCK) Pathway Actomyosin contraction pathway; Calcium-dependent exocytosis
Structure	View full structure page Chemical structure of MS-347a (CAS 144678-18-2)
CAS	144678-18-2
Molecular Formula	C16H12O7
Molecular Weight	316.27
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
NMR Data	1H NMR (DMSO-d6, 500 MHz) [View] [Full page] 13C NMR (DMSO-d6, 125 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (DMSO-d6, 500 MHz) spectrum confirming the structure of MS-347a. Representative 13C NMR (DMSO-d6, 125 MHz) spectrum supporting structural assignment of MS-347a.
Source Organism	Aspergillus udagawae.
Summary	MS-347a is a fungal MLCK inhibitor used to study Ca2+-dependent cytoskeletal contraction.
Details	MS-347a is a fungal secondary metabolite isolated from Aspergillus sp. that irreversibly inhibits smooth muscle myosin light chain kinase (MLCK) with micromolar potency. The compound suppresses phosphorylation of myosin light chain by binding to the catalytic domain of MLCK and inhibits both calmodulin-dependent and calmodulin-independent enzyme activity. MS-347a attenuates sustained Ca2+-dependent exocytosis and inositol trisphosphate signaling without broadly inhibiting other cyclic nucleotide-dependent kinases. It has been used as a mechanistic probe to dissect MLCK-mediated actomyosin regulation and calcium-controlled secretion pathways.
Browse Related	Mechanism MLCK inhibitor Open full index Primary Target Myosin light chain kinase (MLCK) Open full index Pathway Actomyosin contraction pathway; Calcium-dependent exocytosis Open full index Chemical Class Polyketide kinase inhibitor Open full index
Mechanism	MLCK inhibitor
Primary Target	Myosin light chain kinase (MLCK)
Pathway	Actomyosin contraction pathway; Calcium-dependent exocytosis
Chemical Class	Polyketide kinase inhibitor
Discovery Year	1993
Keywords	myosin light chain kinase inhibitor ca2+-dependent exocytosis inhibitor irreversible kinase inhibitor aspergillus metabolite actomyosin regulation research tool
References	Hayashi et al., J Antibiot, 1993 DOI: 10.7164/antibiotics.46.1775 Koshimizu et al., J Biol Chem, 1993 DOI: 10.1016/S0021-9258(17)37404-5 Naor et al., Endocrinology, 1997 DOI: 10.1210/endo.138.4.5078 Yamamoto et al., Biosci Biotechnol Biochem, 2024 DOI: 10.1093/bbb/zbae050
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Representative NMR Data 1H NMR (DMSO-d6, 500 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 13C NMR (DMSO-d6, 125 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 1H NMR (DMSO-d6, 500 MHz) 13C NMR (DMSO-d6, 125 MHz) Representative spectral data. Actual batch data may vary.

MS-347a (CAS: 144678-18-2)