Name: Vermistatin
Brand: Biolinks K.K.
SKU: BLK-1560
Price: 360.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Vermistatin (CAS: 72669-21-7) Product ID: BLK-1560 CAS 72669-21-7 Mechanism Alpha-glucosidase inhibitor Primary Target α-Glucosidase; Aryl hydrocarbon receptor (AhR) Pathway Carbohydrate metabolism pathway; Host signaling modulation
Structure	View full structure page Chemical structure of Vermistatin (CAS 72669-21-7)
CAS	72669-21-7
Molecular Formula	C18H16O6
Molecular Weight	328.32
Price	1mg: USD 360.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95%
NMR Data	1H NMR (CDCl3, 500 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (CDCl3, 500 MHz) spectrum confirming the structure of Vermistatin. Representative 13C NMR (CDCl3, 125 MHz) spectrum supporting structural assignment of Vermistatin.
Source Organism	Talaromyces sp.
Summary	Vermistatin is a fungal funicone-like polyketide that inhibits α-glucosidase.
Details	Vermistatin is a funicone-like polyketide secondary metabolite produced by species of Penicillium and Talaromyces. Biosynthetic regulation studies demonstrated that its production is influenced by carbon and nitrogen sources and metal-ion concentrations. Bioactivity investigations revealed that vermistatin derivatives exhibit α-glucosidase inhibitory activity, with vermistatin analogues displaying single-digit micromolar IC50 values. In antiviral assays against canine coronavirus (CCoV), vermistatin improved cell viability at nontoxic concentrations and strongly suppressed expression of the aryl hydrocarbon receptor (AhR), accompanied by lysosomal alkalinization. These findings define vermistatin as a bioactive fungal metabolite with enzyme-inhibitory and antiviral properties linked to metabolic and host-signaling modulation.
Browse Related	Mechanism Alpha-glucosidase inhibitor Open full index Primary Target α-Glucosidase; Aryl hydrocarbon receptor (AhR) Open full index Pathway Carbohydrate metabolism pathway; Host signaling modulation Open full index Chemical Class Funicone-type polyketide Open full index
Mechanism	Alpha-glucosidase inhibitor
Primary Target	α-Glucosidase; Aryl hydrocarbon receptor (AhR)
Pathway	Carbohydrate metabolism pathway; Host signaling modulation
Chemical Class	Funicone-type polyketide
Discovery Year	1984
Keywords	α-glucosidase inhibitor aryl hydrocarbon receptor (ahr) modulator antiviral compound fungal metabolite penicillium metabolite metabolic research tool
References	Mikami et al., Arch Microbiol, 1984 (regulation of vermistatin biosynthesis in Penicillium vermiculatum) DOI: 10.1007/BF02814580 Zhang et al., Planta Med, 2014 (?-glucosidase inhibitory vermistatin derivatives; X-ray confirmation) DOI: 10.1055/s-0034-1382859 De Luca et al., Antibiotics, 2023 (antiviral activity; AhR suppression; lysosomal alkalinization) DOI: 10.3390/antibiotics12081319
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Representative NMR Data 1H NMR (CDCl3, 500 MHz) Representative spectral data. Actual batch data may vary.

Vermistatin (CAS: 72669-21-7)