Name: NG 011
Brand: Biolinks K.K.
SKU: BLK-1420
Price: 110.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

NG 011 (CAS: 151271-58-8) Product ID: BLK-1420 CAS 151271-58-8 Mechanism Neurite outgrowth enhancer Primary Target Not identified (NGF signaling enhancement) Pathway NGF–TrkA signaling pathway; Neuronal differentiation
Structure	View full structure page Chemical structure of NG 011 (CAS 151271-58-8)
CAS	151271-58-8
Molecular Formula	C32H38O15
Molecular Weight	662.65
Price	1mg: USD 110.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of NG 011. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of NG 011.
Source Organism	Penicillium sp.
Summary	NG 011 is a fungal NGF potentiator that enhances neurite outgrowth in neuronal differentiation assays.
Details	NG-011 is a secondary metabolite isolated from Penicillium verruculosum that enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. It acts as a potentiator of NGF signaling rather than an NGF mimic, increasing neuronal differentiation responses in the presence of NGF. Structural studies revealed that it belongs to a macrocyclic polylactone class of fungal metabolites. NG-011 has been used as a neurobiology research tool to investigate NGF-dependent differentiation pathways and neuronal survival mechanisms.
Browse Related	Mechanism Neurite outgrowth enhancer Open full index Primary Target Not identified (NGF signaling enhancement) Open full index Pathway NGF–TrkA signaling pathway; Neuronal differentiation Open full index Chemical Class Macrocyclic polylactone Open full index
Mechanism	Neurite outgrowth enhancer
Primary Target	Not identified (NGF signaling enhancement)
Pathway	NGF–TrkA signaling pathway; Neuronal differentiation
Chemical Class	Macrocyclic polylactone
Discovery Year	1992
Keywords	nerve growth factor potentiator neurite outgrowth stimulator pc12 differentiation modulator penicillium verruculosum metabolite neurobiology research tool
References	Kobayashi et al., J Antibiot, 1992 DOI: 10.7164/antibiotics.45.1559 Kobayashi et al., J Antibiot, 1992 DOI: 10.7164/antibiotics.45.1566 Kobayashi et al., J Antibiot, 1993 DOI: 10.7164/antibiotics.46.1101
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

NG 011 (CAS: 151271-58-8)