Name: Rasfonin
Brand: Biolinks K.K.
SKU: BLK-1330
Price: 290.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Rasfonin (CAS: 303156-68-5) Product ID: BLK-1330 CAS 303156-68-5 Mechanism KRAS signaling inhibitor Primary Target KRAS Pathway Ras/MAPK signaling pathway
Structure	View full structure page Chemical structure of Rasfonin (CAS 303156-68-5)
CAS	303156-68-5
Molecular Formula	C25H38O6
Molecular Weight	434.57
Price	1mg: USD 290.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Data	1H NMR (CDCl3, 500 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (CDCl3, 500 MHz) spectrum confirming the structure of Rasfonin. Representative 13C NMR (CDCl3, 125 MHz) spectrum supporting structural assignment of Rasfonin.
Source Organism	Trichurus sp.
Summary	Rasfonin is a fungal 2-pyrone metabolite with immunomodulatory and anticancer activity.
Details	Rasfonin is a fungal secondary metabolite first identified as an immunosuppressive compound and later recognized as an inhibitor of KRAS-dependent cancer cell growth. It suppresses Ras/MAPK signaling by reducing Sos1 expression, leading to decreased Ras activation and downstream Raf/MEK/ERK phosphorylation. Rasfonin induces reactive oxygen species generation, activates JNK signaling, and promotes autophagy and caspase-dependent apoptosis. In vivo studies demonstrated inhibition of KRAS-mutant tumor growth.
Browse Related	Mechanism KRAS signaling inhibitor Open full index Primary Target KRAS Open full index Pathway Ras/MAPK signaling pathway Open full index Chemical Class 2-Pyrone polyketide Open full index
Mechanism	KRAS signaling inhibitor
Primary Target	KRAS
Pathway	Ras/MAPK signaling pathway
Chemical Class	2-Pyrone polyketide
Discovery Year	2005
Keywords	ras mapk pathway modulator 2-pyrone derivative autophagy inducer ros activator fungal polyketide apoptosis research compound
References	Kimura et al., Chem Pharm Bull, 2005 DOI: 10.1248/cpb.53.923 Liu et al., Cell Death Dis, 2014 DOI: 10.1038/cddis.2014.213 Zhang et al., Autophagy, 2016 DOI: 10.1080/21501203.2016.1170073 Wang et al., J South Med Univ, 2019 DOI: 10.19723/j.issn.1671-167X.2019.02.006 Hoffmeister et al., Fungal Biol Biotechnol, 2023 DOI: 10.1186/s40694-023-00158-x
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (CDCl3, 500 MHz) Representative spectral data. Actual batch data may vary.

Rasfonin (CAS: 303156-68-5)