Name: Viridicatumtoxin A
Brand: Biolinks K.K.
SKU: BLK-1320
Price: 160.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Viridicatumtoxin A (CAS: 39277-41-3) Product ID: BLK-1320 CAS 39277-41-3 Mechanism Tetracycline-type protein synthesis inhibitor Primary Target Bacterial ribosome (tetracycline-sensitive site) Pathway Bacterial protein translation pathway
Structure	View full structure page Chemical structure of Viridicatumtoxin A (CAS 39277-41-3)
CAS	39277-41-3
Molecular Formula	C30H31NO10
Molecular Weight	565.6
Price	1mg: USD 160.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Viridicatumtoxin A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Viridicatumtoxin A.
Source Organism	Penicillium brasilianum.
Summary	Viridicatumtoxin A is a tetracycline-type fungal polyketide active against MRSA.
Details	Viridicatumtoxin A is a tetracycline-type polyketide originally described as a metabolite of Penicillium viridicatum and structurally related to the tetracycline class of antibiotics. Subsequent studies demonstrated strong antibacterial activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), with potency comparable to vancomycin in related analogues. Mutagenicity assays in Salmonella typhimurium revealed activity after metabolic activation, consistent with its classification among biologically active mycotoxins. Biosynthetic and genomic analyses identified the viridicatumtoxin biosynthetic gene cluster and suggested horizontal gene transfer events between Aspergillus and Penicillium species. These findings define viridicatumtoxin A as a structurally unique tetracycline-type fungal antibiotic with potent anti-MRSA activity.
Browse Related	Mechanism Tetracycline-type protein synthesis inhibitor Open full index Primary Target Bacterial ribosome (tetracycline-sensitive site) Open full index Pathway Bacterial protein translation pathway Open full index Chemical Class Tetracycline-type polyketide Open full index
Mechanism	Tetracycline-type protein synthesis inhibitor
Primary Target	Bacterial ribosome (tetracycline-sensitive site)
Pathway	Bacterial protein translation pathway
Chemical Class	Tetracycline-type polyketide
Discovery Year	1970
Keywords	tetracycline-type polyketide mrsa inhibitor gram-positive bacteria antibacterial penicillium viridicatum metabolite anti-mrsa agent mutagenic after metabolic activation antibiotic research tool
References	van der Merwe et al., Mutation Res, 1978 (mutagenicity in Salmonella after metabolic activation) DOI: 10.1016/0165-1218(78)90009-5 Zhang et al., J Antibiot, 2008 (viridicatumtoxin B isolation; anti-MRSA activity) DOI: 10.1038/ja.2008.84 Nicolau et al., J Am Chem Soc, 2014 (total synthesis; structural revision; SAR) DOI: 10.1021/ja506472u Knowles et al., mSphere, 2020 (viridicatumtoxin BGC; horizontal gene transfer) DOI: 10.1128/mSphere.00156-20
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Viridicatumtoxin A (CAS: 39277-41-3)