Name: Herquline A
Brand: Biolinks K.K.
SKU: BLK-1290
Price: 300.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Herquline A (CAS: 71812-08-3) Product ID: BLK-1290 CAS 71812-08-3 Mechanism Antiviral agent Primary Target Influenza A virus replication machinery Pathway Viral replication pathway
Structure	View full structure page Chemical structure of Herquline A (CAS 71812-08-3)
CAS	71812-08-3
Molecular Formula	C19H26N2O2
Molecular Weight	314.43
Price	1mg: USD 300.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Herquline A. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Herquline A.
Source Organism	Penicillium herquei.
Summary	Herquline A is a fungal piperazine alkaloid with reported anti-influenza activity.
Details	Herquline A is a pentacyclic piperazine alkaloid produced by Penicillium herquei. Originally identified as a weak inhibitor of ADP-induced platelet aggregation, it was later shown to inhibit replication of influenza A virus (A/PR/8/34 strain) in a dose-dependent manner without significant cytotoxicity. Mechanistic studies indicate that herquline A does not inhibit viral neuraminidase, suggesting a distinct antiviral target within the viral replication cycle. Herquline A represents one of the earliest characterized fungal piperazine alkaloids and serves as a structural prototype within this alkaloid class.
Browse Related	Mechanism Antiviral agent Open full index Primary Target Influenza A virus replication machinery Open full index Pathway Viral replication pathway Open full index Chemical Class Piperazine alkaloid Open full index
Mechanism	Antiviral agent
Primary Target	Influenza A virus replication machinery
Pathway	Viral replication pathway
Chemical Class	Piperazine alkaloid
Discovery Year	1979
Keywords	anti-influenza compound viral replication inhibitor piperazine alkaloid penicillium metabolite platelet aggregation inhibitor antiviral research scaffold
References	Omura et al., J Antibiot, 1979 DOI: 10.7164/antibiotics.32.786 Ueda et al., J Antibiot, 2016 DOI: 10.1080/09168451.2016.1162084 Wu et al., Nat Prod Rep, 2022 DOI: 10.1039/d2np00070a
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Herquline A (CAS: 71812-08-3)