Name: Aspochalasin I
Brand: Biolinks K.K.
SKU: BLK-1270
Price: 180.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Aspochalasin I (CAS: 670225-69-1) Product ID: BLK-1270 CAS 670225-69-1 Mechanism Actin polymerization inhibitor Primary Target Not identified (melanogenesis pathway modulation) Pathway Melanin biosynthesis
Structure	View full structure page Chemical structure of Aspochalasin I (CAS 670225-69-1)
CAS	670225-69-1
Molecular Formula	C24H35NO5
Molecular Weight	417.55
Price	1mg: USD 180.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Aspochalasin I. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Aspochalasin I.
Source Organism	Aspergillus sp.
Summary	Aspochalasin I is a cytochalasan that disrupts actin dynamics and suppresses melanin production.
Details	Aspochalasin I is a cytochalasan-type secondary metabolite isolated from Aspergillus species. Its structure was established by spectroscopic analysis including NMR and mass spectrometry. Biologically, aspochalasin I inhibits melanogenesis in Mel-Ab melanocyte cells with an IC50 value of 22.4 µM without detectable cytotoxicity. Although cytochalasans are generally associated with actin cytoskeleton modulation, aspochalasin I has primarily been characterized for its melanin synthesis inhibitory activity.
Browse Related	Mechanism Actin polymerization inhibitor Open full index Primary Target Not identified (melanogenesis pathway modulation) Open full index Pathway Melanin biosynthesis Open full index Chemical Class Cytochalasan (PKS–NRPS hybrid) Open full index
Mechanism	Actin polymerization inhibitor
Primary Target	Not identified (melanogenesis pathway modulation)
Pathway	Melanin biosynthesis
Chemical Class	Cytochalasan (PKS–NRPS hybrid)
Discovery Year	2008
Keywords	cytochalasan actin polymerization modulator melanogenesis inhibitor melanin suppression agent fungal secondary metabolite aspergillus metabolite cytoskeleton research tool
References	Kim YH et al., J Microbiol Biotechnol, 2008, 18:389-393 DOI: 10.4014/jmb.0806.389 Wang G et al., J Nat Prod, 2003, 66:1193-1196 DOI: 10.1021/np030353m
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Aspochalasin I (CAS: 670225-69-1)