Name: Paxilline
Brand: Biolinks K.K.
SKU: BLK-1250
Price: 40.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Paxilline (CAS: 57186-25-1) Product ID: BLK-1250 CAS 57186-25-1 Mechanism BKCa channel blocker Primary Target Large-conductance Ca2+-activated potassium channel (BKCa) Pathway Potassium ion transport; Neuronal excitability signaling
Structure	View full structure page Chemical structure of Paxilline (CAS 57186-25-1)
CAS	57186-25-1
Molecular Formula	C27H33NO4
Molecular Weight	435.57
UN (Transport)	UN2811
Price	1mg: USD 40.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	Paxilline
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Data	1H NMR (CDCl3, 500 MHz) [View] [Full page] 13C NMR (CDCl3, 125 MHz) [View] [Full page]
NMR Spectral Data	Representative 1H NMR (CDCl3, 500 MHz) spectrum confirming the structure of Paxilline. Representative 13C NMR (CDCl3, 125 MHz) spectrum supporting structural assignment of Paxilline.
Source Organism	Penicillium sp.
Summary	Paxillin is a fungal indole-diterpene that inhibits BKCa potassium channels in ion channel research.
Details	Paxilline is a tremorgenic indole-diterpene metabolite originally isolated from Penicillium paxilli and structurally characterized by X-ray crystallography. It functions as a potent and relatively selective blocker of large-conductance Ca2+-activated potassium (BKCa) channels and has become a standard pharmacological tool in electrophysiology. Recent studies also demonstrate inhibition of KCNK18 channels, contributing to sensory neuron activation. Beyond its well-known tremor-inducing neurotoxicity, paxilline is increasingly investigated in cancer and autophagy signaling contexts. Paxilline remains a reference compound for potassium channel modulation and structure-activity studies of indole diterpenes.
Browse Related	Mechanism BKCa channel blocker Open full index Primary Target Large-conductance Ca2+-activated potassium channel (BKCa) Open full index Pathway Potassium ion transport; Neuronal excitability signaling Open full index Chemical Class Indole-diterpene alkaloid Open full index
Mechanism	BKCa channel blocker
Primary Target	Large-conductance Ca2+-activated potassium channel (BKCa)
Pathway	Potassium ion transport; Neuronal excitability signaling
Chemical Class	Indole-diterpene alkaloid
Discovery Year	1975
Keywords	bkca potassium channel inhibitor indole-diterpene alkaloid tremorgenic mycotoxin penicillium paxilli metabolite ion channel research tool
References	Springer et al., Tetrahedron Lett, 1975 DOI: 10.1016/S0040-4039(00)75170-7 Smith et al., Nat Prod Rep, 2022 DOI: 10.1039/D1NP00062D Zhang et al., Sci Rep, 2025 DOI: 10.1038/s41598-025-03044-1 Kim et al., Toxins, 2023 DOI: 10.3390/toxins15010070
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Documents 📄 Safety Data Sheet (SDS) – Download PDF 📄 Product Specification Sheet (PDS) – Download PDF 🧪 Certificate of Manufacture (CofM) – Download HTML
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.
Representative NMR Data 1H NMR (CDCl3, 500 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 13C NMR (CDCl3, 125 MHz) Representative spectral data. Actual batch data may vary.
Representative NMR Data 1H NMR (CDCl3, 500 MHz) 13C NMR (CDCl3, 125 MHz) Representative spectral data. Actual batch data may vary.

Paxilline (CAS: 57186-25-1)