Name: Asperphenamate
Brand: Biolinks K.K.
SKU: BLK-1240
Price: 210.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

Asperphenamate (CAS: 63631-36-7) Product ID: BLK-1240 CAS 63631-36-7 Mechanism Autophagy inducer Primary Target Autophagy regulatory machinery Pathway Nonribosomal peptide biosynthesis
Structure	View full structure page Chemical structure of Asperphenamate (CAS 63631-36-7)
CAS	63631-36-7
Molecular Formula	C32H30N2O4
Molecular Weight	506.6
Price	1mg: USD 210.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Synonyms	N-benzoyl-L-phenylalanine 2-phenylethyl ester
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of Asperphenamate. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of Asperphenamate.
Source Organism	Aspergillus sp.
Summary	Asperphenamate is a fungal NRPS-derived dipeptide ester with reported antitumor activity.
Details	Asperphenamate is a small peptide-derived natural product originally isolated from Aspergillus species. Its biosynthesis involves a unique two-module nonribosomal peptide synthetase (NRPS) system composed of ApmA and ApmB, which cooperate to generate an amino acid ester structure. This represents the first characterized fungal two-module NRPS mechanism for amino acid ester formation. Biologically, asperphenamate exhibits antiproliferative activity in multiple cancer cell lines and has been shown to induce autophagic cell death rather than apoptosis. Structural modification studies have further demonstrated that synthetic derivatives can enhance anticancer potency, highlighting asperphenamate as a promising scaffold for anticancer drug development.
Browse Related	Mechanism Autophagy inducer Open full index Primary Target Autophagy regulatory machinery Open full index Pathway Nonribosomal peptide biosynthesis Open full index Chemical Class NRPS-derived dipeptide ester Open full index
Mechanism	Autophagy inducer
Primary Target	Autophagy regulatory machinery
Pathway	Nonribosomal peptide biosynthesis
Chemical Class	NRPS-derived dipeptide ester
Discovery Year	1976
Keywords	nonribosomal peptide synthetase product autophagy inducer antitumor natural product dipeptide ester two-module nrps-derived compound fungal metabolite natural product research scaffold
References	Guo CJ et al., Chem Sci, 2017, 8:5278-5285 DOI: 10.1039/c7sc02396k Liu X et al., Eur J Med Chem, 2016, 110:130-140 DOI: 10.1016/j.ejmech.2016.01.020 Kildgaard S et al., Front Microbiol, 2020, 11:618730 DOI: 10.3389/fmicb.2020.618730
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

Asperphenamate (CAS: 63631-36-7)