Name: 10,11-Dehydrocurvularin
Brand: Biolinks K.K.
SKU: BLK-1230
Price: 90.00 USD
Availability: InStock

For Research Use Only. Not for human or veterinary use.

10,11-Dehydrocurvularin (CAS: 1095588-70-7) Product ID: BLK-1230 CAS 1095588-70-7 Mechanism NLRP3 inflammasome inhibitor Primary Target NLRP3 inflammasome complex Pathway NLRP3 inflammasome signaling pathway
Structure	View full structure page Chemical structure of 10,11-Dehydrocurvularin (CAS 1095588-70-7)
CAS	1095588-70-7
Molecular Formula	C16H18O5
Molecular Weight	290.31
Price	1mg: USD 90.00 / 5mg: - / 25mg: -
Storage	-20°C
Solubility	1mg/ml ethanol, methanol, DMSO
Purity	>95% [View LC/UV Data]
LC/UV	Representative LC/UV chromatogram under typical analytical conditions (C18 column; mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min; flow rate: 0.2 mL/min; detection: 210 nm).
NMR Spectral Data	Representative 1H NMR (500 MHz) spectrum confirming the structure of 10,11-Dehydrocurvularin. Representative 13C NMR (125 MHz) spectrum supporting structural assignment of 10,11-Dehydrocurvularin.
Source Organism	Aspergillus sp.
Summary	10,11-Dehydrocurvularin is a benzenediol lactone macrolide that suppresses NLRP3 inflammasome activation.
Details	10,11-Dehydrocurvularin is a 12-membered benzenediol lactone (BDL) macrolide produced by diverse fungal species as a secondary metabolite. It selectively inhibits NLRP3 inflammasome activation by interfering with the NEK7-NLRP3 interaction, resulting in reduced caspase-1 activation and diminished IL-1β secretion. The C=C double bond at positions 10,11 is essential for its inflammasome inhibitory activity. Beyond anti-inflammatory effects, 10,11-dehydrocurvularin exhibits cytotoxic and antitumor activities, making it a valuable scaffold for inflammasome biology and inflammation-related drug discovery.
Browse Related	Mechanism NLRP3 inflammasome inhibitor Open full index Primary Target NLRP3 inflammasome complex Open full index Pathway NLRP3 inflammasome signaling pathway Open full index Chemical Class Benzenediol lactone (RAL-type) Open full index
Mechanism	NLRP3 inflammasome inhibitor
Primary Target	NLRP3 inflammasome complex
Pathway	NLRP3 inflammasome signaling pathway
Chemical Class	Benzenediol lactone (RAL-type)
Discovery Year	1968
Keywords	nlrp3 inflammasome inhibitor nek7-nlrp3 interaction disruptor il-1β suppressor caspase-1 inhibitor benzenediol lactone macrolide fungal polyketide inflammasome pathway research tool
References	Barnes et al., J Toxicol Environ Health, 1976 DOI: 10.1080/03601237609372044 Zhang et al., Acta Pharm Sin B, 2023 DOI: 10.1016/S1875-5364(23)60418-2 Li et al., Curr Med Chem, 2021 DOI: 10.2174/1389557521666210428132256 Liu et al., J Antibiot, 2015 DOI: 10.1038/ja.2015.85
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Representative LC/UV Data HPLC Conditions (typical): Column: C18 Mobile phase: 5–100% ACN / H2O (0.05% H3PO4), linear gradient 20 min Flow rate: 0.2 mL/min Detection: 210 nm Representative analytical data. Actual batch data may vary.

10,11-Dehydrocurvularin (CAS: 1095588-70-7)